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Interventions consisted of mitochondrial modulator therapy: N -acetylcysteine, acetyl-l-carnitine, S -adenosylmethionine, coenzyme Q10, alpha-lipoic acid, creatine monohydrate, vitamin C, vitamin D, vitamin E, melatonin, omega-3 polyunsaturated fatty acids, inositol, silymarin, folic acid, resveratrol, sulforaphane, and lithium [4, 13,14,15]